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15 12, 2014

Differences between Steroidal and Nonsteroidal Aromatase Inhibitors

2014-12-28T18:45:31+00:00

Aromatase inhibitors (AIs) are approved for use in both early and advanced-stage breast cancer in postmenopausal women. Although the currently approved “third-generation” AIs all powerfully inhibit estrogen synthesis, they may be subdivided into steroidal and nonsteroidal inhibitors, which interact with the aromatase enzyme differently. Nonsteroidal AIs bind non- covalently and reversibly to the aromatase protein, [...]

15 08, 2014

Ten Years of Tamoxifen Reduces Breast Cancer Recurrences, Improves Survival

2017-04-26T12:34:59+00:00

For some women with Breast Cancer, taking adjuvant tamoxifen  for 10 years after primary treatment leads to a greater reduction in breast cancer recurrences and deaths than taking the drug for only 5 years, according to the results of a large international clinical trial. The findings from the ATLAS trial—presented at the San Antonio Breast Cancer Symposium  (SABCS) and published in The [...]